Avtor/Urednik		Kett, DH; Azoulay, E; Echeverria, PM; Vincent, JL; Muzlovič, I; Ožek, B; Tomič, V; Knafelj, R; Švigelj, V
Naslov		Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
Tip		članek
Vir		Crit Care Med
Vol. in št.		Letnik 39, št. 4
Leto izdaje		2011
Obseg		str. 665-70
Jezik		eng
Abstrakt		Objectives: To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. DESIGN: A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge. Sstting: EPIC II included 1265 intensive care units in 76 countries. Patients: Patients in participating intensive care units on study day. Interventions: None. Measurement and main results: Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .05) and appeared to have been in an intensive care unit longer (14 days [range, 5-25 days], 8 days [range, 3-20 days], and 10 days [range, 2-23 days], respectively), but this difference was not statistically significant. Severity of illness and organ dysfunction scores were similar between groups. Patients with Candida bloodstream infections, compared with patients with Gram-positive and Gram-negative bloodstream infections, had the greatest crude intensive care unit mortality rates (42.6%, 25.3%, and 29. (Abs. trunc. at 2000 ch.)
Deskriptorji		AGED ANTIFUNGAL AGENTS CANDIDA ALBICANS CANDIDIASIS CROSS INFECTION FLUCONAZOLE INTENSIVE CARE UNITS PREVALENCE RETROSPECTIVE STUDIES SEPSIS