Avtor/Urednik		Marčun, Robert; Sustic, Alan; Meško-Brguljan, Pika; Kadivec, Saša; Farkaš, Jerneja; Košnik, Mitja; Coats, Andrew J; Anker, Stefan D; Lainščak, Mitja
Naslov		Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease
Tip		članek
Vir		Int J Cardiol
Vol. in št.		Letnik 161, št. 3
Leto izdaje		2012
Obseg		str. 156-9
Jezik		eng
Abstrakt		Purpose: In chronic obstructive pulmonary disease (COPD), cardiovascular system is involved but less is known about role of specific cardiac biomarkers. We aimed to investigate associations between N-terminal pro B-type natriuretic peptide (NT-proBNP) and troponin T during hospitalisation with 6-month outcome. Methods: This was a prospective study conducted in consecutive patients hospitalized for an acute exacerbation of COPD. On admission, and at discharge, NT-proBNP and troponin T were measured, and echocardiography was performed. Hospitalisations and mortality were recorded for 6months after discharge. Results: We included 127 patients (70+/-10years, 70% men, GOLD III/IV 87%). Left ventricular dysfunction was detected in 70 (55%) patients and diastolic dysfunction was the most common type (53 patients-42%). NT-proBNP and troponin T were elevated on admission in 60% and 36%, and at discharge in 28% and 19% of patients. During follow-up, 53 (42%) patients were hospitalized and 17 (13%) patients died. In Kaplan Meier analysis of survival curves, NT-proBNP on admission distinguished between deceased and surviving patients (p=0.011) whilst troponin T at discharge separated hospitalized and non-hospitalized patients (p=0.017). The adjusted Cox proportional hazard model confirmed these findings: discharge troponin T predicted hospitalisations (hazard ratio 2.89, 95% confidence interval 1.13-7.36) and admission NT-proBNP predicted mortality (hazard ratio 4.20, 95% confidence interval 1.07-14.01). Conclusions: Elevated NT-proBNP at discharge and troponin T on admission predict outcome in patients hospitalized for an acute exacerbation of COPD.
Deskriptorji		LUNG DISEASES, OBSTRUCTIVE VENTRICULAR DYSFUNCTION, LEFT NATRIURETIC HORMONE TROPONIN HOSPITALIZATION AGED TREATMENT OUTCOME SURVIVAL ANALYSIS