Avtor/Urednik		Cvetko, E; Karen, P; Eržen, I
Naslov		Wearing of complete dentures reduces slow fibre and enhances hybrid fibre fraction in masseter muscle
Tip		članek
Vir		J Oral Rehabil
Vol. in št.		Letnik 39, št. 8
Leto izdaje		2012
Obseg		str. 608-14
Jezik		eng
Abstrakt		Edentulous conditions and use of complete dentures alter the function of jaw muscles, which is presumably reflected in the myosin heavy chain (MyHC) isoform composition. This study is the first dealing with MyHC isoforms expression in edentulous persons with the aim to clarify to which extent the decreased functional load following teeth loss contributes to the changed muscle phenotype during ageing. We analysed MyHC expression in old masseter muscle at decreased and full functional load by comparing age-matched edentulous and dentate subjects. Edentulous subjects had upper and lower complete dentures. Dentate subjects had at least 24 natural teeth in continuous dental arches with two molars present in each quadrant and normal intermaxillary relationship. The adaptive response to the reduced masticatory load was lower numerical and area proportion of MyHC-1 expressing fibres and higher numerical proportion of hybrid fibres in edentulous compared with dentate subjects with no significant difference in the proportion of MyHC-neo-expressing fibres between both groups. We conclude that the observed differences in the proportion of fibre types between denture wearers and dentate subjects cannot be ascribed to degenerative changes intrinsic to the ageing muscle, but to functional differences in muscle activity and to morphological alterations of stomatognathic system accompanying the complete teeth loss.
Deskriptorji		JAW, EDENTULOUS DENTURE, COMPLETE MASSETER MUSCLE MYOSIN HEAVY CHAINS MUSCLE FIBERS MUSCLE FIBERS, SLOW-TWITCH IMMUNOHISTOCHEMISTRY AGED