Avtor/Urednik		Salobir, B
Naslov		Vpliv aktivnosti avtonomnega živčevja in upornosti perifernega ožilja na razvoj esencialne arterijske hipertenzije
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1993
Obseg		str. 38
Jezik		slo
Abstrakt		To evaluate the presence of autonomic nervous dysfunction (an increased sympathetic drive combined with decreased parasympathetic activity) in healthy, young, normotensive, subjects with genetic predisposition for essential hypertension, two groups of subjects at different degrees of risk for hypertension were compared: 106 offspring of hypertensive parents (I), and 161 offspring of normotensive parents (II). In both groups beside autonomic. nervous activity, the forearm hemodynamics (blood flow and vascular resistance) in resting conditions and during peak reactive hyperaemia was assessed. The autonomic nervous function was assessed by heart rate spectral analysis. The balance between sympathetic and parasympathetic activity in supine and standing position was compared by quantifying the amplitude of the low (LFB), mid (MFB) and high frequency bands (HFB). In supine position no significant differences in integrals over the frequency bands between the groups were found (LFB: I - 2,75 q0,99 vs. II -'2,78 q0,84; MFB: I - 3,33 q0,12 vs. II - 3,28 q0,11; HFB: I - 5,09 q0,21 vs. II - 5,15 q0,18;). In standing position the integrals over the LFB (I - 4,76 q0,13 vs. II - 4,46 q0,13, p=0,05;) and the HFB (I - 4,14 q0,18 vs. II - 3,64 q0,17, p=Ð,02;) were significantly higher in offspring of hypertensive parents, but no differences in the MFB were, found (I - 5,09 q0,19 vs. II - 4,86 q0,18;). The differences in the integrals over frequency bands between the two groups demonstrate increased sympathetic activity during standing in a group with a familial predisposition for hypertensio n, while no difference in parasympathetic drive was found. Offspring of hypertensives in comparison with control subjects had greater forearm blood flow (FABF: I - 2,57 q0,14 versus II - 2,31 q0,14 ml/min/100 ml tissue, p=0,03;), but no difference in forearm vascular resistance (FAVR: I 40,02 q2,30 versus II - 42,82 q2,28, p greather th.(trunc.)
Deskriptorji		HYPERTENSION HEART RATE SPECTRUM ANALYSIS AUTONOMIC NERVOUS SYSTEM VASCULAR RESISTANCE BLOOD PRESSURE DETERMINATION ADULT PLETHYSMOGRAPHY AGE FACTORS BODY HEIGHT BODY WEIGHT MEDICAL HISTORY TAKING FAMILY