Avtor/Urednik		Mladenova, Zornitsa; Papp, Hajnalka; Lengyel, Gyoergy; Kisfali, Peter; Steyer, Andrej; Steyer, Adela F; Esona, Mathew D; Iturriza-Gomara, Miren; Banyai, Krisztian
Naslov		Detection of rare reassortant G5P[6] rotavirus, Bulgaria
Tip		članek
Vir		Infect Genet Evol
Vol. in št.		Letnik 12, št. 8
Leto izdaje		2012
Obseg		str. 1676-84
Jezik		eng
Abstrakt		During the ongoing rotavirus strain surveillance program conducted in Bulgaria, an unusual human rotavirus A (RVA) strain, RVA/Human/BG/BG620/2008/G5P[6], was identified among 2200 genotyped Bulgarian RVAs. This strain showed the following genomic configuration: G5-P[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1. Phylogenetic analysis of the genes encoding the neutralization proteins and backbone genes identified a probable mixture of RVA genes of human and porcine origin. The VP1, VP6 and NSP2 genes were more closely related to typical human rotavirus strains. The remaining eight genes were either closely related to typical porcine and unusual human-porcine reassortant rotavirus strains or were equally distant from reference human and porcine strains. This study is the first to report an unusual rotavirus isolate with G5P[6] genotype in Europe which has most likely emerged from zoonotic transmission. The absence of porcine rotavirus sequence data from this area did not permit to assess if the suspected ancestral zoonotic porcine strain already had human rotavirus genes in its genome when transmitted from pig to human, or, the transmission was coupled or followed by gene reassortment event(s). Because our strain shared no neutralization antigens with rotavirus vaccines used for routine immunization in children, attention is needed to monitor if this G-P combination will be able to emerge in human populations. A better understanding of the ecology of rotavirus zoonoses requires simultaneous monitoring of rotavirus strains in humans and animals.
Deskriptorji		ROTAVIRUS ROTAVIRUS INFECTIONS GENOTYPE GENOME, VIRAL DISEASE RESERVOIRS SWINE VIRAL VACCINES BULGARIA