Avtor/Urednik		Vujasinović, Miroslav; Kikec, Zdenko; Hafner, Matjaž; Ferlan-Marolt, Vera
Naslov		S ciprofloksacinom povzročena holestatska okvara jeter - prikaz primera
Prevedeni naslov		Ciprofloxacin-induced cholestatic liver injury - a case report
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 81, št. 9
Leto izdaje		2012
Obseg		str. 676-80
Jezik		slo
Abstrakt		Background: Drug-induced liver injury has been described for a large number of drugs. It is a common cause of drug withdrawal from the market. Ciprofloxacin is a commonly prescribed fluoroquinolone antibiotic and is a rare cause of hepatotoxicity. To our best knowledge this is the first case of ciprofloxacin-induced cholestatic liver injury in Slovenia. Case report: A 19year old man has been treated with ciprofloxacin at a daily dose of 500 mg twice a day due to a mild respiratory infection. After twenty days he was admitted to hospital because of jaundice. Laboratory findings showed a typical pattern of acute cholestatic liver failure, which was additionally confirmed by the liver biopsy. The patient was treated symptomatically. Ten months later the patient's clinical status is stabile with a normal bilirubin level and mildly elevated alkaline phosphatase and gamma-glutamyltransferase. Conclusion: Although severe hepatotoxicity after the administration of ciprofloxacin is rare, physicians should be cautious and alert to its side-effects.
Deskriptorji		CIPROFLOXACIN LIVER DISEASES CHOLESTASIS, INTRAHEPATIC ADULT