Avtor/Urednik     Blaganje, Mija; Lukanovič, Adolf
Naslov     Intrasphincteric autologous myoblast injections with electrical stimulation for stress urinary incontinence
Tip     članek
Vir     Int J Gynaecol Obstet
Vol. in št.     Letnik 117, št. 2
Leto izdaje     2012
Obseg     str. 164-7
Jezik     eng
Abstrakt     Methods Autologous myoblasts isolated from a biceps muscle sample were injected under transurethral ultrasound guidance into the external urethral sphincter of 38 female patients. The patients also underwent ES postoperatively to enhance cell integration. Treatment feasibility, as well aspossible intraoperative and postoperative complications, was assessed 6 weeks after the injections. Additionally, the effects of the myoblast injections followed by an ES cycle were compared to those of a preoperative EScycle undergone by the same patients. Results No serious adverse events or complications were noted and the procedure was well tolerated. Compared with the objective and subjective measurements collected after the preoperative ES cycle, the corresponding measurements obtained 6 weeks postoperatively, after the completion of a second ES cycle, indicated considerable improvement. The results to the stress test were negative for 29 (78.4%) of the patients, 5 (13.5%) considered their SUI cured, and 29 (78.4%) reported improvement. Conclusion Intrasphincteric autologous myoblast injections followed by ES is minimally invasive and feasible, and safely produced promising initial results.