Avtor/Urednik | Budihna, NV; Milčinski, M; Kajtna-Koselj, M; Malovrh, M | |
Naslov | Relevance of Tc-99m DMSA scintigraphy in renal transplant parenchymal imaging | |
Tip | članek | |
Vir | Clin Nucl Med | |
Vol. in št. | Letnik 19, št. 9 | |
Leto izdaje | 1994 | |
Obseg | str. 782-4 | |
Jezik | eng | |
Abstrakt | Tc-99m DMSA renal scintigraphy was performed in 40 renal grafts. Cyclosporin A and glucocorticoids were given to all patients as antirejection therapy, and 11 also were given azathioprine. The kidneys were transplanted 1 to 97 months before the investigation. Seventy percent of kidneys had diffusely altered distribution of Tc-99m DMSA, and 43 percent had focal clear-cut parenchymal defects. The frequency of parenchymal defects observed on the DMSA scans was higher in patients who suffered manifest acute rejection episodes (8/16 versus 9/24 patients, borderline significance, P less th. 0.06), but had no relation to the living or cadaveric donor transplant or its function. A combination of peritubular edema and interstitial fibrosis is considered the most probable explanation of diffuse changes. The high frequency of clear-cut parenchymal defects most likely results from symptomatic or asymptomatic rejection episodes complicated by renal transplant infarcts. | |
Deskriptorji | GRAFT REJECTION KIDNEY KIDNEY TRANSPLANTATION ORGANOTECHNETIUM COMPOUNDS SUCCIMER ACUTE DISEASE ADULT AZATHIOPRINE CREATININE CYCLOSPORINE EDEMA FIBROSIS GLUCOCORTICOIDS GRAFT REJECTION INFARCTION KIDNEY KIDNEY TRANSPLANTATION KIDNEY TUBULES MIDDLE AGE ORGANOTECHNETIUM COMPOUNDS SUCCIMER |