Avtor/Urednik		Bevc, Sebastjan; Hojs, Radovan; Ekart, Robert; Završnik, Matej; Gorenjak, Maksimiljan; Puklavec, Ludvik
Naslov		Simple cystatin C formula for estimation of glomerular filtration rate in overweight patients with diabetes mellitus type 2 and chronic kidney disease
Tip		članek
Vol. in št.		Letnik 2012
Leto izdaje		2012
Obseg		str. article ID 179849 (str. 1-8)
ISSN		1687-5303 - Experimental diabetes research
Jezik		eng
Abstrakt		In clinical practice the glomerular filtration rate (GFR) is estimated from serum creatinine-based equations like the Cockcroft-Gault formula (C&G) and Modification of Diet in Renal Disease formula (MDRD). Recently, serum cystatin C-based equations, the newer creatinine formula (The Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)), and equation that use both serum creatinine and cystatin C (CKD-EPI creatinine & cystatin formula) were proposed as new GFR markers. Present study compares serum creatinine-based equations, combined (including both serum creatinine and cystatin C) equation, and serum simple cystatin C formula (100/serum cystatin C) against 51CrEDTA clearance in 113 adult overweight Caucasians with diabetes mellitus type 2 (DM2) and chronic kidney disease (CKD). The results of present study demonstrated that the simple cystatin C formula could be a useful tool for the evaluation of renal function in overweight patients with DM2 and impaired kidney function in daily clinical practice in hospital and especially in outpatients. Despite the advantages of the simple cystatin C formula, cystatin C-based equations cannot completely replace the gold standard for estimation of the GFR in a population of DM2 patients with CKD, but may contribute to a more accurate selection of patients requiring such invasive and costly procedures.
Deskriptorji		Diabetes Mellitus, Type 2 Sladkorna bolezen, tip 2 Kidney Failure, Chronic Ledvična odpoved, kronična Cystatin C Cistatin C Glomerular Filtration Rate Glomerulna filtracija, hitrost Overweight Prekomerna telesna teža