Avtor/Urednik		Geršak, K; Meden-Vrtovec, H; Tomaževič, T
Naslov		Effect of GnRH agonist treatment on follicular development in women with polycystic ovary syndrome in the IVF-ET program
Tip		članek
Vir		Adv Contracept Deliv Syst
Vol. in št.		Letnik 8, št. 1,2
Leto izdaje		1992
Obseg		str. 107-13
Jezik		eng
Abstrakt		Forty women with polycystic ovary syndrome, divided into two groups, were treated with or without GnRA agonist prior to ovulation induction with gonadotropins. The criteria for diagnosis were: LH:FSH ratio more that 2.0, menstrual cycle abnormalities, polycystic ovaries diagnosed by laparoscopy, obesity with or without hirsutism and polycystic ovarian response to classical ovulation induction, i.e. more than 8 follicles greather th. 10 mm in diameter in each ovary at the time of HCG administration. In the first group, Buserelin was given subcutaneously 500 micro g once per day started on the second day of the cycle until the parameters indicating pituitary desensitization were present: absence of follicles greather th. 5 mm, serum E2 less th. 0.10 nmol/L, serum LH less th. 2 IU/L. Blood samples were taken every 2 days during the first week of treatment and then every day for RIA of LH, FSH and sex steroids. Desensitization was achieved in 15.2 +- 6.3 (mean +- SD) days and LH:FSH ratio decreased to 0.60 +- 0.35. During ovarian stimulation desensitization was continued by daily s.c. administration of 100 micro g of Buserelin until the day of hMG administration in the treated group. Duration of stimulation was 7.15 +- 0.81 days with 14.7 +2.9 ampules hMG in the control group. Comparing the results of E2 level on the day of hCG administration, the number and size of all observed and aspirated follicles, oocyte recovery rate, fertilization rate and the number of embryos replaced, no significant differences were found between the two groups. In summary, these data show that short pretreatment with GnRA agonist can temporarily correct endocrine abnormalities of polycystic ovary syndrome without influencing multiple follicular development.
Deskriptorji		POLYCYSTIC OVARY SYNDROME GONADORELIN OVULATION INDUCTION GONADOTROPINS, CHORIONIC EMBRYO TRANSFER FERTILIZATION IN VITRO LH FSH RADIOIMMUNOASSAY OOCYTES