Avtor/Urednik		Fleischmann, CM
Naslov		Tumor studies using tumor cells resistant to interferon
Prevedeni naslov		Odpornost tumorskih celic za interferon
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 63, št. Suppl 2
Leto izdaje		1994
Obseg		str. II-23-II-2
Jezik		eng
Abstrakt		Background. An understanding of the contributions of the various IFN-induced antitumor effects would be beneficial for decision making regarding the clinical use of the IFN. Methods. Physiologically IFN-resistant B16 melanoma cells (B16alpha res cells) were studied in an in vivo tumor model. Results. B16 melanoma cells resistant to the in vitro antiproliferative effects of IFN were more sensitive to the in vivo antitumor effects of the same IFN. Conculsion. The B16alpha res cells are useful for the study of IFN induced host-mediated antitumor effects and appear to be significantly more immunogenic than the B16 cells.
Deskriptorji		MELANOMA, EXPERIMENTAL INTERFERON-ALPHA MICE ANIMALS, LABORATORY SURVIVAL RATE