Avtor/Urednik		Škamperle, Mateja; Kocjan, Boštjan; Maver Vodičar, Polona; Seme, Katja; Poljak, Mario
Naslov		Human papillomavirus (HPV) prevalence and HPV type distribution in cervical, vulvar, and anal cancers in central and eastern Europe
Tip		članek
Vol. in št.		Letnik 22, št. 1
Leto izdaje		2013
Obseg		str. 1-5
ISSN		1318-4458 - Acta dermatovenerologica Alpina, Panonica, et Adriatica
Jezik		eng
Abstrakt		Introduction: High-risk human papillomaviruses (HPV) play the leading etiological role in the development of cervical, anal, and vaginal cancers and a substantial proportion of penile, vulvar, and oropharyngeal (tonsillar) cancers. Methods: The article summarizes the results of the most important studies that examined tissue specimens of cervical, anal, and vulvar carcinoma from 16 central and eastern European countries for the presence of HPV DNA. Results: Twenty-eight eligible studies were identified. Among 2,531 invasive cervical cancers, 86.6% were HPV-positive. The combined prevalence of HPV-16/18 among HPV-positive cervical cancers was 87.5%. The overall prevalence of HPV DNA in six studies of anal carcinomas (43 cases) and vulvar carcinomas (164 cases) was 90.7% and 32.9%, respectively. HPV-16 DNA was detected in 86% of all anal carcinomas studied, and the proportion of HPV-16 positive vulvar carcinomas varied from 10.9% to 27.5%. HPV-18 DNA was not detected in any anal or vulvar carcinoma studied. Conclusions: HPV prevalence and type distribution among women with cervical cancer in central and eastern Europe is comparable with other European regions. Several gaps in knowledge exist in the region concerning HPV prevalence and type distribution among women with HPV-related cancers other than cervical cancer and in the general population.
Proste vsebinske oznake		HPV virusi razvoj raka diagnostika centralna in vzhodna Evropa