Avtor/Urednik     Režonja, Katja; Lorenzon, Paola; Marš, Tomaž
Naslov     Opposing effects of dexamethasone, agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cells
Tip     članek
Vol. in št.     Letnik 549
Leto izdaje     2013
Obseg     str. 186-190
ISSN     0304-3940 - Neuroscience letters
Jezik     eng
Abstrakt     Neuromuscular junction development is the key process required for successful neuromuscular transmission and functional innervation of skeletal muscle fibres. Various substances can influence these processes, some of which are in common use in clinical practice. In the present study, the effects of the potentially new therapeutic agent agrin were followed, along with the widely used glucocorticoid dexamethasone. The in vitro experimental model used was functional innervation and constitutive interleukin 6 (IL-6) secretion of human muscle cells. Additionally, the selective relaxant binding agent sugammadex and its possible interaction with dexamethasone were followed. Dexamethasone impaired functional innervation while agrin had opposing effects. Furthermore, based on interference with IL-6 secretion, we show potential (chemical) interactions between dexamethasone and sugammadex. The physiological effects of this interaction should be taken into consideration under clinical conditions where these two drugs might be applied simultaneously.
Proste vsebinske oznake     neuromuscular junction
dexamethasone
interleukin 6
nevromišični spoj
deksametazon
interlevkin 6