Avtor/Urednik		Hojker, S
Naslov		Vpliv uporabe radioaktivnega joda v medicini na incidenco malignomov: retrospektivna epidemiološka študija v Sloveniji za obdobje 1963-1980
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1994
Obseg		str. 90
Jezik		slo
Abstrakt		A retrospective follow-up study of 18294 patients, examined with 131I for suspected thyroid disorders between years 1963 and 1980, was conducted. The average dose was 4.6 MBq. Among them, 2627 patients were at least once treated with, on average, 868 MBq of 131I. The mean age at the time of the first examination (exposure) was 46 years; 3 percent were under the age of 20. The follow up started with exposure and end with date of death, date of lost to follow-up or 31. december 1988. The average length of the follow-up was 14.8 years. Record linkage with the Cancer registry of Slovenia identified 1375 cancers during the follow-up. The patients who had ever developed cancer were significantly older (p less th. 0.005) than those without cancer. The incidence of functional disturbances and of nodular changes in the thyroid gland was significantly greater (p less th. 0.005) among the patients with cancer. The calculation of expected number of cancers was based on cancer incidence rates in Slovenia per 100 000 inhabitants, adjusted by sex, age, and calendar period. Standardised incidence ratio (SIR) is a ratio between expected and observed number of cancers. Among patients treated with 131I SIR for all cancers was not increased in any period during the follow-up. By contrast, SIR was sinificantly increased among females receiving only diagnostic doses of 131I 18 -19 years after the exposure (SIR =1.41, 95 percent confidence interval (CI) =1.03 -1.89). The group of women receiving only diagnostic dose was split in four exposure categories, according to the number of received diagn ostic doses. SIR was increased in the period of 10 to 19 years after the exposure only in the group of women receiving more than 3 diagnostic doses (SIR =1.89, CI =1.21- 2.80). The significantly positive dose-response trend was observed in the period of 10 to 19 years after the exposure (p less th. 0.005). When specific cancer sites were studued, excess risk of breast cancer (SIR = 1.(trunc.)
Deskriptorji		IODINE RADIOISOTOPES NEOPLASMS THYROID NEOPLASMS SLOVENIA INCIDENCE AGE FACTORS SEX FACTORS RADIATION DOSAGE