Avtor/Urednik		Vrtovec, Bojan; Sever, Matjaž; Domanovič, Dragoslav; Ležaič, Luka; Poglajen, Gregor; Černelč, Peter; Haddad, F.; Torre-Amione, Guillermo
Naslov		Long-term effects of stem cell transplantation in heart failure
Prevedeni naslov		Dolgoročni učinki presaditve matičnih celic pri bolnikih s srčnim popuščanjem
Tip		članek
Vir		In: 4. kongres hematologov in transfuziologov Slovenije z mednarodno udeležbo : Olimje, 12.-14. 4. 2012 : Olimje, 12.-14. April 2012 Ljubljana : Slovensko zdravniško društvo
Vol. in št.		Letnik 81, št. suppl.
Leto izdaje		2012
Obseg		str. II-373-II-383
Jezik		eng
Abstrakt		Background: We investigated long-term effects of intracoronary transplantationof CD34+ cells in patients with dilated cardiomyopathy (DCM). Methods: Of 110 DCM patients, 55 were randomized to CD34+ cell transplantation(SC) group, and 55 patients received no cell therapy (controls). In the SC group, peripheral CD34+cells were mobilized by G-CSF andcollected via apheresis. Patients underwent myocardial scintigraphy and CD34+ cells were injected in the artery supplying the segments with reduced viability. Patients were followed for 5 years. Results: At baseline, the 2 groups did not differ in age, gender, left ventricular ejection fraction (LVEF), or NT-proBNP levels. At 5 years, stem cell therapy was associated withan increase in LVEF (from 24.3 Ž 6.5 % to 30.0 Ž 5.1 %; P = 0.02), an increase in 6-minute walk distance (from 344 Ž 90 m to 477 Ž 130 m; P < 0.001), and a decrease in NT-proBNP (from 2322 Ž 1234 pg/mL to 1011 Ž 893 pg/mL; P < 0.01). During followup, 27 (25 %) patients died and 9 (8 %) underwent heart transplantation. Of the 27 deaths, 13 were attributed to pump failure, and 14 to sudden cardiac death. Total mortality was lower in SC group(8/55 [14 %]) than in controls (19/55 [35 %]) (P = 0.01). The same was true of pump failure (3/55 [5 %] vs. 10/55 [18 %], P = 0.03), but not of sudden cardiac death (5/55 [9 %] vs. 9/55 [16 %], P = 0.39). SC therapy was anindependent predictor of outcome on multivariable analysis (P = 0.04). Conclusions: Intracoronary stem cell transplantation may be associated with improved ventricular remodeling, exercise tolerance, and longterm survival in patients with DCM.
Proste vsebinske oznake		matične celice dilativna kardiomiopatija srčno popuščanje stem cells dilated cardiomyopathy heart failure