Avtor/Urednik		Ogorevc, Eva; Kralj-Iglič, Veronika; Veranič, Peter
Naslov		Are extracellular vesicles involved in phenotypic oncogenic transformation?
Prevedeni naslov		[Pomen zunajceličnih veziklov v rakasti transformaciji celic]
Tip		članek
Vol. in št.		Letnik 47, št. 3
Leto izdaje		2013
Obseg		str. 197-205
ISSN		1318-2099 - Radiology and oncology
Jezik		eng
Abstrakt		Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.
Proste vsebinske oznake		extracellular vesicles cancer oncogenic transformation cells zunajcelični vezikli rak rakasta transformacija celic