Avtor/Urednik		Bordyugov, Grigory; Westermark, P. O.; Korenčič, Anja; Bernard, S.; Herzel, Hanspeter
Naslov		Mathematical modeling in chronobiology
Tip		članek
Vir		In: Circadian clocks Heidelberg New York : Springer
Leto izdaje		2013
Obseg		str. 335-357
Jezik		eng
Abstrakt		Circadian clocks are autonomous oscillators entrained by external Zeitgebers such as lightdark and temperature cycles. On the cellular level, rhythms are generated by negative transcriptional feedback loops. In mammals, the suprachiasmatic nucleus (SCN) in the anterior part of the hypothalamus plays the role of the central circadian pacemaker. Coupling between individual neurons in the SCN leads to precise self-sustained oscillations even in the absence of external signals. These neuronal rhythms orchestrate the phasing of circadian oscillations in peripheral organs. Altogether, the mammalian circadian system can be regarded as a network of coupled oscillators. In order to understand the dynamic complexity of these rhythms, mathematical models successfully complement experimental investigations. Here we discuss basic ideas of modeling on three different levels (1) rhythm generation in single cells by delayed negative feedbacks, (2) synchronization of cells via external stimuli or cellcell coupling, and (3) optimization of chronotherapy.
Proste vsebinske oznake		modelling oscillations synchronization modeliranje oscilacije sinhronizacija