Avtor/Urednik		Lunder, M; Podrumac, B; Dragoš, V; Smrkolj, A; Lunder, T
Naslov		Naše izkušnje pri zdravljenju mikrosporije, 1985-1992
Prevedeni naslov		The treatment of microsporum canis infection, 1985-1992
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 64, št. 1
Leto izdaje		1995
Obseg		str. 21-3
Jezik		slo
Abstrakt		Background. Microsporum canis infection has a high prevalence in Slovenia. A retrospective survey conducted at the Department of Dermatology in Ljubljana covered most patients with M. canis infection treated in the period 1985-1992. The aim of the study was to evaluate the results of two treatment methods: topical therapy given alone or in combination with oral griseofulvin. Methods. A total of 1011 cases of M. canis infection were analysed. In all the patients the clinical diagnosis was confirmed by positive laboratory results. Most patients were treated on an out-patient basis, only 15.5 percent were admitted to the hospital. Results. The greatest proportion of patients were children under eleven years of age. The infection was more common in girls (60.1 percent) than in boys (39.9 percent). The majority of patients (95.5 percent) were treated with griseofulvin in daily doses of 10-20 mg/kg BW, combined with topical miconazole. Only 4.5 percent of the patients received topical therapy alone. Complete recovery was observed after an average treatment period of 9.6 weeks (range 2 to 52 weeks). Scalp infections showed the slowest response to the therapy. The average duration of treatment with the combined regiment was 8.5 weeks, whereas topical treatment lasted appreciably longer, on average 13.9 weeks. Conclusions. The site and spread of disease foci had a significant effect on the duration of therapy. The most refractory cases were those involving multiple foci on the scalp. Combined treatment with oral and local antifungals was more effective than topical therapy alone. Th ese results are important from the clinical as well as from the epidemiological point of view.
Izvleček		Izhodišča. Mikrosporija (Microsporum canis) je v Sloveniji zelo razširjena. Naredili smo retrospektivno analizo večine bolnikov z mikrosporijo, ki so bili v letih 1985 do 1992 zdravljeni na Dermatološki kliniki v Ljubljani. Namen raziskave je bil ugotoviti uspešnost zdravljenja ob upoštevanju različnih dejavnikov. Primerjali smo 2 načina zdravljenja med seboj (kombinirano: Griseofulvin tablete in lokalni antimikotik in samo lokalno zdravljenje). Metode. Iz obdobja 1985-1992 smo analizirali 1011 bolnikov z mikrosporijo. Pri vseh je bila klinična diagnoza potrjena z laboratorijskim izvidom. Večino bolnikov smo zdravili ambulantno, le 15,5 odst. je bilo hospitaliziranih. Rezultati. Med bolniki so prevladovali otroci do 11. leta starosti, več (60,1 odst.) je bilo deklic kot dečkov (39,9 odst.). Večino bolnikov (95,5 odst.) smo zdravili kombinirano (Griseofulvin 10-20 mg/kg telesne teže/dan in lokalno antimikotik Mikonazol, le 4,5 odst. bolnikov smo zdravili samo lokalno. Popolna ozdravitev je nastopila povprečno po 9,6 tednih z razponom med 2 in 52 tedni. Najdaljše zdravljenje je bilo potrebno pri mikrosporiji lasišča. Kombinirano zdravljenje je bilo znatno krajše (povprečno 8,5 tedna) kot le lokalno (povprečno 13,9 tedna). Zaključki. Na čas zdravljenja mikrosporije je pomembno vplivala lokalizacija in razširjenost bolezenskih žarišč. Najbolj neugodni so bili primeri s številnimi žarišči na lasišču. Kombinirano, to je peroralno in lokalno antimikotično zdravljenje je bilo pri naših bolnikih uspešnejše, kar je pomembno iz zdravstvenega in epidemiološkega vidika.
Deskriptorji		DERMATOMYCOSES MICROSPORUM MICONAZOLE GRISEOFULVIN