Avtor/Urednik		Vrtovec, Bojan; Radovančević, Rajko; Delgado, Reynolds M.; Radovancevic, Branislav; Bracey, Arthur W.; Gregorič, Igor; Frazier, O.H.
Naslov		Significance of anaemia in patients with advanced heart failure receiving long-term mechanical circulatory support
Tip		članek
Vol. in št.		Letnik 11Letnik 10
Leto izdaje		2009
Obseg		str. 1000-1004
ISSN		1388-9842 - European journal of heart failure
Jezik		eng
Abstrakt		Aims The aim of this study was to analyse the prognostic impact of anaemia in patients receiving long-term left ventricular assist device (LVAD) support. Methods and results We reviewed the data of 65 consecutive patients who underwent LVAD support for at least 6 months. Anaemia was defined as haemoglobin levels <12.0 g/dL. Follow-up was performed 15 months after implantation. Anaemia was present in 30/65 patients (46%) after 6 months of LVAD support. Anaemic patients had higher levels of pre-implant creatinine (1.8 % 0.8 vs. 1.4 % 0.5 mg/dL; P = 0.04). The presence of anaemia after 6 months correlated with higher levels of creatinine and blood urea nitrogen and lower levels of albumin. Multivariate Cox proportional hazards regression analysis revealed that levels of haemoglobin <12 g/dL [risk ratio (RR), 8.94; 95% confidence interval (CI), 1.09%73.01; P = 0.04], creatinine >1.4 mg/dL (RR, 5.39; 95% CI, 1.78%16.30; P = 0.003), and albumin <1.5 g/L (RR, 3.23; 95% CI, 1.10%9.51; P = 0.03) were associated with all-cause mortality at 15 months. Long-term survival evaluated by Kaplan%Meier analysis was two times higher in non-anaemic patients after 6 months of LVAD support than in anaemic patients (P = 0.01). Conclusion Anaemia is related to adverse outcomes in patients receiving prolonged LVAD support.
Proste vsebinske oznake		device LVAD anaemia survival naprava LVAD anemija preživetje