Avtor/Urednik		Šarc, Lucija; Jamšek, Marija; Grenc, Damjan; Brvar, Miran
Naslov		Smernice za zdravljenje zastrupitev s paracetamolom
Prevedeni naslov		Guidelines for paracetamol poisoning treatment
Tip		članek
Vol. in št.		Letnik 83, št. 3
Leto izdaje		2014
Obseg		str. 201-208
ISSN		1581-0224 - Zdravniški vestnik
Jezik		slv
Abstrakt		Paracetamol overdose results in an accumulation of the reactive, hepatotoxic metabolite N-acetyl-p-benzoquinoneimin (NAPKQI) which can cause serious liver injury. Recognition of paracetamol overdose, hepatotoxicity risk estimation and early treatment are crutial in paracetamol poisoniong management. In ingestion of potential hepatotoxic dose of paracetamol decontamination and early treatment with N-acetylcysteine (NAC) are indicated. Both, 20-hours intravenous and 72-hurs oral regimes of NAC administration are successful. By antidote regime selection we should consider patient condition and time after paracetamol overdose. In severe hepatotoxicity, criteria for liver transplantation should be regularly evaluated and mechanisms for liver transplantation must be activated in time.
Proste vsebinske oznake		paracetamol poisoning liver injury paracetamol zastrupitev jetrna odpoved