Avtor/Urednik		Kores-Plesničar, Blanka
Naslov		Efficacy and tolerability of agomelatine in the treatment of depression
Tip		članek
Vol. in št.		Letnik 8
Leto izdaje		2014
Obseg		str. 603-612
ISSN		1177-889X - Patient preference and adherence
Jezik		eng
Abstrakt		Depression is a severe and usually recurrent mental disorder which often leads to a significant impairment of everyday functioning, a reduced quality of life, and also great suffering of the patients. The treatment of a depressive disorder is not only limited to acute treatment; it also requires prolonged management. Patient compliance is of utmost importance. Unpleasant adverse effects and their impact on everyday living often lead to a premature discontinuation of antidepressant treatment and result in an unfavorable treatment outcome. The new antidepressant agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, has exhibited good antidepressant efficacy in acute, short-term, and long-term treatment. The adverse effect profile of agomelatine has been proven to be favorable and comparable to placebo, which is very important for good treatment compliance and adherence.
Proste vsebinske oznake		agomelatine cicardian rhythms depression agomelatin cikadni ritem depresija