Avtor/Urednik		Kandus, A; Ponikvar, R; Drinovec, J; Kladnik, S; Ivanovich, P
Naslov		Anaphylatoxins C3a and C5a adsorption on acrylonitrile membrane of hollow-fiber and plate dialyzer--an in vivo study
Tip		članek
Vir		Int J Artif Organs
Vol. in št.		Letnik 13, št. 3
Leto izdaje		1990
Obseg		str. 176-80
Jezik		eng
Abstrakt		We studied the adsorption of anaphylatoxins C3a and C5a on acrylonitrile (AN69) hollow-fiber (AN69HF) and plate (AN69P) dialyzers in 8 patients during 4-hour hemodialyses (HD). Blood passed first through a cuprophan dialyzer and then through AN69 dialyzers that were not in contact with dialysis fluid. Plasma C3a and C5a were measured in samples taken from the afferent and efferent blood lines of the acrylonitrile dialyzers at 15, 60 and 240 min. Plasma C3a concentrations decreased significantly in blood that had passed through AN69 dialyzers. This decrease, indicating membrane adsorption, was maximal (by 65 percent in AN69HF and by 59 percent in AN69P) at 15 min and minimal (by 53 percent in AN69HF and by 18 percent in AN69P) at 240 min. The decrease in plasma C5a concentrations was smaller and significant throughout HD only with AN69HF. The amount of C3a adsorbed was at least 45,000 micrograms in AN69HF and 18,000 micrograms in AN69P. These findings demonstrate that acrylonitrile dialyzers adsorb more C3a and C5a than they produce. This membrane adsorption may explain why the increase of plasma C3a and C5a is inhibited during HD.
Deskriptorji		COMPLEMENT 3A COMPLEMENT 5A KIDNEY, ARTIFICIAL MEMBRANES, ARTIFICIAL ACRYLONITRILE ADSORPTION ADULT AGED COMPLEMENT ACTIVATION HEMODIALYSIS KIDNEY FAILURE, CHRONIC MIDDLE AGE TIME FACTORS