Avtor/Urednik		Šeruga, Boštjan; Zadnik, Vesna; Grašič-Kuhar, Cvetka; Marinko, Tanja; Čufer, Tanja; Zakotnik, Branko; Zorman, Darko; Ocaña, Alberto; Amir, Eitan
Naslov		Association of aromatase inhibitors with coronary heart disease in women with early breast cancer
Tip		članek
Vol. in št.		Letnik 32, št. 4
Leto izdaje		2014
Obseg		str. 99-104
ISSN		0735-7907 - Cancer investigation
Jezik		eng
Abstrakt		As compared to tamoxifen aromatase inhibitors (AIs) may increase the risk of heart disease. Here we explored the association between the use of AIs and coronary artery disease (CAD) in a population-based observational study. In a small and heterogeneous population of 74 women with early breast cancer who received adjuvant hormonal therapy and subsequently underwent cardiac angiography, AIs significantly increased the hazard for CAD (HR 3.23, 95% confidence intervals [CI] 1.26-8.25, p = .01) compared to tamoxifen. Our results suggest that therapy with AIs may increase the risk for CAD.
Proste vsebinske oznake		rak dojke zaviralci inhibitorji koronarne bolezni aromatase inhibitor coronary artery disease angiography