Avtor/Urednik		Szebeni, Janos; Wahl, SMharon; Popovic, Mikulas; Wahl, L Marry; Gartner, Suzanne; Fine, Robert L; Skalerič, Uroš; Friedmann, Robert M; Weinstein, John N
Naslov		Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages
Tip		članek
Vir		Proc Natl Acad Sci U S A
Vol. in št.		Letnik 86, št. 10
Leto izdaje		1989
Obseg		str. 3842-6
Jezik		eng
Abstrakt		Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.
Deskriptorji		ANTIVIRAL AGENTS DIPYRIDAMOLE HIV VIRUS REPLICATION ZIDOVUDINE BIOLOGICAL TRANSPORT BONE MARROW CELL SURVIVAL DIDEOXYNUCLEOSIDES DRUG SYNERGISM HIV INTERFERON TYPE I MACROPHAGES MONOCYTES