Avtor/Urednik		Bešić, Nikola; Bešič, Hana; Perić, Barbara; Pilko, Gašper; Petrič, Rok; Žmuc, Jan; Dzodić, Radan; Perhavec, Andraž
Naslov		Surgical treatment of breast cancer in patients aged 80 years or older - how much is enough?
Tip		članek
Leto izdaje		2014
Obseg		str. [1-7]
ISSN		1471-2407 - BMC cancer
Jezik		eng
Abstrakt		Abstract BACKGROUND: The population of elderly people is increasing and so is the population of breast cancer patients aged >=80 years. The aim of our retrospective study was to identify independent prognostic factors for the duration of breast cancer-specific survival of surgically treated patients aged >=80 years. The secondary aim was to determine the appropriate surgical treatment of breast cancer in patients aged >=80 years. METHODS: We reviewed the medical records of 154 patients aged >=80 years with early-stage breast cancer (mean age 83 years) who underwent surgery at the tertiary cancer center in the period from 2000 to 2008. Tumor stage was pT1/pT2 and pT3/pT4 in 75% and 25%, respectively. Surgical treatment comprised: quadrantectomy (in 27%), mastectomy (in 73%), axillary dissection (in 57%), and sentinel lymph node biopsy (in 18%), while 25% of patients had no axillary surgery. RESULTS: During a median follow-up of 5.3 years, 31% of patients died of breast cancer, while 28% of patients died of other causes. Half of our patients with poorly differentiated breast cancer or estrogen receptor-negative tumor died of breast cancer. Multivariate statistical analysis showed that the pathological T-stage, pathological N-stage and estrogen receptors were independent prognostic factors for the duration of breast cancer-specific survival of patients. CONCLUSION: Short breast cancer-specific survival indicates that, in patients aged >=80 years, breast cancer with metastases in axillary lymph nodes can be an aggressive disease.
Proste vsebinske oznake		rak dojke starejši zdravljenje prognoza breast cancer elderly treatment prognosis