Avtor/Urednik		Lindič, J; Bren, AF; Ferluga, D; Drinovec, J; Guček, A; Hvala, A
Naslov		Are there different morphological changes of parietal peritoneum in diabetic and nondiabetic uremic patients prior to continuous ambulatory peritoneal dialysis?
Tip		članek
Vir		Artif Organs
Vol. in št.		Letnik 14, št. Suppl 3
Leto izdaje		1990
Obseg		str. 285-7
Jezik		eng
Abstrakt		From June 1983 to May 1989, 51 patients (28 men, 23 women) aged 25-78 years (56.1 +- 16.9) were treated with continuous ambulatory peritoneal dialysis (CAPD). Twenty-four of them were diabetics. Twenty-seven had surgical biopsies of the parietal peritoneum from the anterior abdominal wall made during the first insertion of the CAPD catheter. A 10 percent solution of neutral buffered formalin and McDowell was used for fixation of the parietal peritoneum Specimens were prepared for light microscopy (hematoxylin eosin, Trichrome, Masson, PAS, van Giesson-Weigert, SAB) and transmission electron microscopy (OsO4, Epon 812). In diabetics, submesothelic collagen fibers were multiplied, compared with nondiabeticss, and penetrated into the scarce fat tissue. Elastic fibers were not multiplied to the same extent. The whole thickness of the submesothelium was 2-3 times greater, and the distance of first-line small vessels from the mesothelium was increased 3-5 times. The basal membrane of the small vessels was continuous in diabetics too, but thicker. The number of mast cells was comparable in diabetics and nondiabetics: mast cells were rare and located in the deep sumbesothelium near vessels. These findings support the theory that glucose in the peritoneal dialysis solution cooperates in inducing posttreatment changes of the parietal peritoneum, verified by biopsy in nondiabetic patients after a long-term CAPD treatment program.
Deskriptorji		PERITONEUM DIABETES MELLITUS PERITONEAL DIALYSIS, CONTINUOUS AMBULATORY