Avtor/Urednik		Gabbasov, Zufar; Sabo, Jan; Petrovič, Danijel; Martell-Claros, Nieves; Zagatina, Angela; Mrdovic, Igor; Ciccocioppo, Rachele; Cangemi, Giuseppina Cristina; Klimas, Jan; Kruzliak, Peter
Naslov		Impact of platelet phenotype on myocardial infarction
Tip		članek
Vol. in št.		Letnik 20, št. 1
Leto izdaje		2015
Obseg		str. 17-25
ISSN		1366-5804 - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Jezik		eng
Abstrakt		In acute myocardial infarction patients the injured vascular wall triggers thrombus formation in the damage site. Fibrin fibers and blood cellular elements are the major components of thrombus formed in acute occlusion of coronary arteries. It has been established that the initial thrombus is primarily composed of activated platelets rapidly stabilized by fibrin fibers. This review highlights the role of platelet membrane phenotype in pathophysiology of myocardial infarction. Here, we regard platelet phenotype as quantitative and qualitative parameters of the plasma membrane outer surface, which are crucial for platelet participation in blood coagulation, development of local inflammation and tissue repair.
Proste vsebinske oznake		platelets platelet phenotype cardiovascular risk trombociti trombocitov fenotip kardiovaskularno tveganje