Avtor/Urednik		Štalc, A; Šentjurc, M; Pečar, S
Naslov		On the topography of the active centre of acetylcholinesterase
Tip		članek
Vir		Vestn Slov Kem Druš
Vol. in št.		Letnik 39, št. 2
Leto izdaje		1992
Obseg		str. 243-57
Jezik		eng
Abstrakt		An overview of our electron paramagnetic resonance (EPR) investigation of the microgeography of membrane acetylcholinesterase (AChE) with a series of fluorophsphate and fluorophosphonate spin labels, selectively bound to the active site of the AChE in the membrane of Torpedo marmorata electric organ, is presented. The pocket-like structure of the enzyme, together with some dimensions of this pocket is described, as well as some changes in its structure which are the result of different influences. The pocket-like structure of the AChE active site obtained by EPR some years ago, corroboates recently published active site conformation obtained by the use of monoclonal antibodies and by X-ray crystallographic structure.
Deskriptorji		ACETYLCHOLINESTERASE BINDING SITES TORPEDO ELECTRIC ORGAN ELECTRON SPIN RESONANCE SPECTROSCOPY ORGANOPHOSPHORUS COMPOUNDS