Avtor/Urednik		Saba, Nabil F.; Haigentz, Missak; Vermorken, Jan; Strojan, Primož; Bossi, Paolo; Rinaldo, Alessandra; Takes, Robert P.; Ferlito, Alfio
Naslov		Prevention of head and neck squamous cell carcinoma
Tip		članek
Vol. in št.		Letnik 51, št. 1
Leto izdaje		2015
Obseg		str. 112-118
ISSN		1368-8375 - Oral oncology
Jezik		eng
Abstrakt		The concept of chemoprevention whereby the use of a systemic agent is intended to halt the carcinogenesis process has been an attractive topic in head and neck squamous cell carcinoma (HNSCC). Yet, despite the significant efforts over the past decades and the substantial gain in knowledge of the biology of pre-malignant lesions of the head and neck, no tangible indications for chemoprevention have emerged for this disease. The negative results observed in the earlier larger studies using retinoids did not encourage further trials with these agents. Attention has been more recently focused on epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) as well as cyclo-oxygenase 2 (COX-2) inhibitors with early studies showing encouraging responses but rather poor tolerance to therapy. Natural compounds have gained more interest recently given preclinical evidence of activity as well as a low side effect profile. We herein offer a comprehensive overview of the field of chemoprevention in HNSCC with an in depth analysis of the challenges we face and discuss a road map for future directions.
Proste vsebinske oznake		rak glave in vratu kemozaščita predmaligne lezije oralna displasija chemoprevention head and neck cancer premalignant lesions oral dysplasia