Avtor/Urednik		Montana, Vedrana; Verkhratsky, Alexei; Parpura, Vladimir
Naslov		Pathological role for exocytotic glutamate release from astrocytes in hepatic encephalopathy
Tip		članek
Vol. in št.		Letnik 12, št. 4
Leto izdaje		2014
Obseg		str. 324-333
ISSN		1570-159X - Current neuropharmacology
Jezik		eng
Abstrakt		Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmotic stress that causes modification of proteins and RNA. Consequently, protein expression and function are affected, including that of glutamine synthetase and plasmalemmal glutamate transporters, leading to glutamate excitotoxicity; Ca(2+)-dependent exocytotic glutamate release from astrocytes contributes to this extracellular glutamate overload.
Proste vsebinske oznake		hepatic encephalopathy exocytosis astrocytes jetrna encefalopatija eksocitoza astrociti