Avtor/Urednik		Verkhratsky, Alexei; Pankratov, Yuri; Lalo, Ulyana; Nedergaard, Maiken
Naslov		P2X receptors in neuroglia
Tip		članek
Vol. in št.		Letnik 1, št. 2
Leto izdaje		2012
Obseg		str. 1-16
ISSN		2190-4618 - Wiley interdisciplinary reviews. Membrane transport and signaling
Jezik		eng
Abstrakt		Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X 1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca 2+ and Na + concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X 4 and P2X 7 receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors.
Proste vsebinske oznake		astrocytes neuroglia P2X receptors astrociti nevroglija P2X receptorji