Avtor/Urednik		Heneka, Michael T; Rodríguez, José J.; Verkhratsky, Alexei
Naslov		Neuroglia in neurodegeneration
Tip		članek
Vol. in št.		Letnik 63, št. 1/2
Leto izdaje		2010
Obseg		str. 189-211
ISSN		0165-0173 - Brain research reviews
Jezik		eng
Abstrakt		Neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia. The neurodegenerative diseases disrupt connectivity within brain circuits affecting neuronal-neuronal, neuronal-glial and glial%glial contacts. In addition neurodegenerative processes trigger universal and conserved glial reactions represented by astrogliosis and microglial activation. The complex of recently acquired knowledge allows us to regard the neurodegenerative diseases as primarily gliodegenerative processes, in which glial cells determine the progression and outcome of neuropathological process.
Proste vsebinske oznake		glia astrocyte microglia neurodegeneration Alzheimer's disease Parkinson's disease dementia amyotrophic lateral sclerosis