Avtor/Urednik		Kirischuk, Sergei; Parpura, Vladimir; Verkhratsky, Alexei
Naslov		Sodium dynamics
Tip		članek
Vol. in št.		Letnik 35, št. 8
Leto izdaje		2012
Obseg		str. 497-506
ISSN		0166-2236 - Trends in neurosciences
Jezik		eng
Abstrakt		Astroglial excitability is largely mediated by fluctuations in intracellular ion concentrations. In addition to generally acknowledged Ca2+ excitability of astroglia, recent studies have demonstrated that neuronal activity triggers transient increases in the cytosolic Na+ concentration ([Na+]i) in perisynaptic astrocytes. These [Na+]i transients are controlled by multiple Na+-permeable channels and Na+-dependent transporters; spatiotemporally organized [Na+]i dynamics in turn regulate diverse astroglial homeostatic responses such as metabolic/signaling utilization of lactate and glutamate, transmembrane transport of neurotransmitters and K+ buffering. In particular, near-membrane [Na+]i transients determine the rate and the direction of the transmembrane transport of GABA and Ca2+. We discuss here the role of Na+ in the regulation of various systems that mediate fast bidirectional communication between neurones and glia at the single synapse level.
Proste vsebinske oznake		astrocytes sodium dynamics Na+/K+ ATPase Na+/Ca2+ exchanger glutamate transporter GABA transporter