Avtor/Urednik		Parpura, Vladimir; Verkhratsky, Alexei
Naslov		Homeostatic function of astrocytes
Tip		članek
Vol. in št.		Letnik 3, št. 4
Leto izdaje		2012
Obseg		str. 334-344
ISSN		2081-6936 - Translational neuroscience
Jezik		eng
Abstrakt		The name astroglia unifies many non-excitable neural cells that act as primary homeostatic cells in the nervous system. Neuronal activity triggers multiple homeostatic responses of astroglia that include increase in metabolic activity and synthesis of neuronal preferred energy substrate lactate, clearance of neurotransmitters and buffering of extracellular K+ ions to name but a few. Many (if not all) of astroglial homeostatic responses are controlled by dynamic changes in the cytoplasmic concentration of two cations, Ca2+ and Na+. Intracellular concentration of these ions is tightly controlled by several transporters and can be rapidly affected by the activation of respective fluxes through ionic channels or ion exchangers. Here, we provide a comprehensive review of astroglial Ca2+ and Na+ signalling.
Proste vsebinske oznake		astrocyte homeostasis excitability Ca2+ signalling Na+ signalling