Avtor/Urednik     Luzar, Boštjan; Shanesmith, Rebecca; Calonje, Eduardo
Naslov     Perineural growth of benign cutaneous sweat gland tumours
Tip     članek
Vol. in št.     , št. Vol.
Leto izdaje     2015
ISSN     0303-6987 - Journal of cutaneous pathology
Jezik     eng
Abstrakt     Background Cutaneous intraneural reactive epithelial proliferations mimicking malignancy include epithelial sheath neuroma, re-excision perineural invasion and reactive neuroepithelial aggregates. Nevertheless, intraneural growth of benign sweat gland tumors has not been reported before. Aims To report a predominantly intraneural proliferation of morphologically bland sweat gland tumors, describe their clinicopathological features and correlate them with survival. Results We analyzed a spiradenoma and a hidradenoma with a prominent intraneural growth, occurring on the back of the 19-year-old woman and on the arm of the 53-year-old woman. Both lesions presented as a painful and slightly raised papule. After complete excision, an uneventful clinical course was observed during the follow-up period of 52 and 54 months. Pathologically, the most striking feature was an almost exclusive intraneural growth within the peripheral nerves of the deep dermis and subcutis. Conclusion We report for the first time the predominantly intraneural growth of benign sweat gland tumors. Although their histogenesis is unknown, perineural displacement due to previous surgery or trauma, as well as development from intraneural embryological epithelial remnants remains possibilities. Long-term follow-up of our patients suggests that intraneural growth of otherwise bland sweat gland tumors does not signify malignancy. Complete excision appears to be sufficient treatment procedure.
Proste vsebinske oznake     neoplasms
spiradenoma
prognosis
neoplazme
spiradenom
prognoza