Avtor/Urednik		Uršič-Vrščaj, M; Poljak, M
Naslov		Voznik ali sopotnik? Pomen okužbe s humanimi virusi papiloma v etiologiji nekaterih novotvorb pri človeku
Prevedeni naslov		Driver or companion-traveller? Role of the human papillomaviruses infection in etiology of some human tumours
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 64, št. 4
Leto izdaje		1995
Obseg		str. 223-8
Jezik		slo
Abstrakt		Background. Infection with certain human papillomavirus (HPV) types are intimately linked with squamous epithelial cell benign and malignant lesions of the lower genital tract, the upper part of the respiratory and digestive system and the skin, in both men and women. This relationship can be appreciated on many levels, as demonstrated by a wealth of molecular, experimental, morphological, and clinical data. Conclusions. The association between HPV and neoplasia is so strong that the virus is central to strategies designed to reduce the risk of squamous carcinoma of the lower genital tract in women. The purpose of this presentation is to provide a brief summary of what is known about HPV and some human neoplasms, to address issues germane to the translation of this information into patient management, and to briefly present results of some HPV studies done in Slovenia.
Izvleček		Izhodišča. Okužba z določenimi tipi humanih virusov papiloma (HVP) je tesno povezana z vznikom in razvojem nekaterih benignih in malignih sprememb ploščatoceličnega epitela v genitalnem traktu, zgornjem delu dihalne in prebavne poti in na koži. Dokaz te povezave je skupni rezultat številnih molekularnih, morfoloških in kliničnih raziskav. Zaključki. Povezava med okužbo s HVP in nastankom nekaterih novotvorb, npr. raka materničnega vratu, je tako očitna, da zavzema zgodnje odkrivanje virusov osrednjo vlogo v strategiji načrtovanega boja za zmanjšanje incidence teh tumorjev. Namen tega prispevka je na kratko opisati nekatera novejša dognanja o povezavi med okužbo s HVP in nastankom določenih novotvorb pri človeku, opisati načine za prenos teh dognanj v vsakodnevno klinično delo ter predstaviti rezultate dosedanjih raziskav HVP, opravljenih v Sloveniji.
Deskriptorji		NEOPLASMS PAPILLOMAVIRUS CERVIX NEOPLASMS LARYNGEAL NEOPLASMS ESOPHAGEAL NEOPLASMS PAPOVAVIRIDAE INFECTIONS TUMOR VIRUS INFECTIONS