Avtor/Urednik     Luzar, Boštjan; Tanaka, Maiko; Schneider, Johann; Calonje, Eduardo
Naslov     Cutaneous microcystic/reticular schwannoma
Tip     članek
Vol. in št.     , št. Vol.
Leto izdaje     2015
ISSN     0303-6987 - Journal of cutaneous pathology
Jezik     eng
Abstrakt     Background Microcystic/reticular schwannoma is exceptionally rare yet distinctive morphological variant of schwannoma with predilection for visceral sites lacking association with neurofibromatosis. Aims To further delineate clinicopathological features of cutaneous microcystic/reticular schwannoma and to discuss its differential diagnosis. Results We analysed three cutaneous microcystic/reticular schwannomas, occurring in two males and one female (mean age 37.6 yrs). The tumors presented as a non-painful slightly raised papule (mean 0.7 cm) on upper arm (n=2) and back (n=1). No recurrences were observed despite marginal excision (mean follow-up 42 months). Histopathologically, a multilobular proliferation was present in the dermis composed of bland tumor cells forming distinctive microcystic, reticular, lace-like or pseudoglandular structures, containing abundant myxoid/mucinous material. By immunohistochemistry, tumor cells lining microcystic structures corresponded to Schwann cells (diffuse S100 positive, variable GFAP positivity). A discontinuous EMA positive perineurium was present at the periphery of some of the lobules. Conclusion Cutaneous microcystic/reticular schwannoma expands the spectrum of benign peripheral nerve sheath tumors with reticular morphology encountered in the skin. Other tumors in this group include reticular perineurioma and hybrid tumors with reticular morphology, e.g. reticular perineurioma/schwannoma and reticular perineurioma/neurofibroma.
Proste vsebinske oznake     benign peripheral nerve tumors
skin
reticular hybrid tumors
benigni tumorji perifernih živcev
koža
retikularni hibridni tumorji