Avtor/Urednik		Kolenc, Matej; Kobal, Jan; Podnar, Simon
Naslov		Male sexual function in presymptomatic gene carriers and patients with Huntington's disease
Tip		članek
Vol. in št.		Letnik 359, št. 1/2
Leto izdaje		2015
Obseg		str. 312-317
ISSN		0022-510X - Journal of the neurological sciences
Jezik		eng
Abstrakt		Aims: To report sexual dysfunction in a systematically studied cohort of men with Huntington's disease (HD), and compare them with control men of a similar age. Methods: In men with HD and asymptomatic HD gene carriers, the male sexual dysfunction questionnaire (International Index of Erectile Function - IIEF, covering erectile and orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction), neurologic assessment using the Unified Huntington's Disease Rating Scale (UHDRS) and the Total Functional Capacity (TFC) Score were utilized. Results: Responses were obtained from 23 HD patients and 2 HD gene carriers. HD patients reported more problems with erection, intercourse satisfaction and overall satisfaction (p < 0.05) compared to 41 controls. HD patients generally reported reduced sexual desire and performance. Sexual dysfunction progressed in parallel with patients' decline in motor (UHDRS) and TFC, but was not related to patients' age and duration of disease. Conclusions: Our study demonstrated a significant impact of HD on male sexual function that progressed in parallel with motor and total patient (TFC) dysfunction. Physicians helping HD patients should also consider this largely neglected aspect of the disease
Proste vsebinske oznake		erection Huntington's disease male sexual dysfunction sexual questionnaire deterioration of sexual function autonomic dysfunction depression total functional capacity