Avtor/Urednik		Brecl Jakob, Gregor; Pelykh, Olena; Košutzká, Zuzana; Pirtošek, Zvezdan; Trošt, Maja; Ilmberger, Joseph; Valkovic, Peter; Mehrkens, Jan H.; Bötzel, Kai
Naslov		Postural stability under globus pallidus internus stimulation for dystonia
Tip		članek
Vol. in št.		Letnik 126, št. 12
Leto izdaje		2015
Obseg		str. 2299-2305
ISSN		1388-2457 - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Jezik		eng
Abstrakt		Objective Deep brain stimulation of the globus pallidus internus (GPi-DBS) is an efficient and safe treatment for medically refractory dystonia. However, recent studies reported gait problems, falls and bradykinesia in patients after the DBS procedure. The aim of this study was to quantify the effect of GPi-DBS on postural performance in patients with cranio-cervical dystonia. Methods Thirteen patients with focal/segmental dystonia and GPi-DBS participated in the study. We performed two postural tests (pull test and push and release test) in on- and off-stimulation conditions and recorded the movements of the patients with inertial sensors. Results Under stimulation patients exhibited a higher number of steps (p=0.015), reduced first step length (p=0.011) and lower stepping velocity (p=0.001), compared to off stimulation. We observed a higher number of steps in the push and release test compared to the pull test (p=0.038). The interaction between stimulation condition and test type was significant (p=0.027). Conclusions The velocity and amplitude of postural reactions are compromised by GPi-DBS in patients with cranio-cervical dystonia. Significance This information corresponds to patient%s reports of falls and postural instability after GPi-DBS. Pre-operatively, patients should be informed about the possibility of the occurrence of such phenomena.
Proste vsebinske oznake		dystonia globus pallidus deep brain stimulation postural balance