Avtor/Urednik		Mujezinović, Faris; Alfirević, Žarko
Naslov		Procedure-related complications of amniocentesis and chorionic villous sampling
Tip		članek
Vol. in št.		Letnik 110, št. 3
Leto izdaje		2007
Obseg		str. 687-694
ISSN		0029-7844 - Obstetrics and gynecology
Jezik		eng
Abstrakt		Objective: To compile a systematic review of complications related to genetic amniocentesis and chorionic villus sampling (CVS) to provide benchmark data for counseling and performance assessment of individual operators. Data sources: We searched the MEDLINE database for articles published after January 1, 1995, that reported data for at least 100 women with singleton pregnancies with genetic amniocentesis after 14 weeks of pregnancy and reports of CVS carried out transabdominally between 10 and 14 weeks. Methods of study selection: For amniocentesis, 29 articles fulfilled search criteria. Sixteen studies fulfilled search criteria for CVS. Tabulation, integration, and results: After genetic amniocentesis, pooled pregnancy loss within 14 days was 0.6% (95% confidence interval [CI] 0.5-0.7), rising to 0.9% (95% CI 0.6-1.3) for pregnancy loss before 24 weeks and 1.9% (95% CI 1.4-2.5) for total pregnancy loss. Corresponding figures for CVS were 0.7%, 1.3%, and 2%. The data on multiple insertions showed large heterogeneity, ranging from 0.2% to 2.9% for amniocentesis (pooled risk 2.0%, 95% CI 0.9-3.6) and from 1.4% to 26.6% for CVS (pooled risk 7.8%, 95% CI 3.1-14.2). Only five amniocentesis studies provided controls, but none was matched for gestational age. Pooled relative risks for fetal loss before 28 weeks and total pregnancy loss were 1.46 (95% CI 0.86-2.49) and 1.25 (95% CI 1.02-1.53), respectively. Conclusion: Although the risks of pregnancy loss are relatively low, lack of adequate controls tends to underestimate the true added risk of prenatal invasive procedures.
Deskriptorji		Amniocentesis Amniocenteza Chorionic Villi Sampling Horionske resice, vzorčenje Gestational Age Gestacijska starost Chromosome Aberrations Kromosomske aberacije Fetal Death Plodova smrt Pregnancy Outcome Nosečnost, izid complications adverse effects Zapleti Stranski učinki