Avtor/Urednik		Hellquist, Henrik; Skálová, Alena; Barnes, Leon; Cardesa, Antonio; Thompson, Lester D. R.; Triantafyllou, Asterios; Williams, Michelle D.; Devaney, Kenneth O.; Gnepp, Douglas R.; Bishop, Justin A.; Strojan, Primož
Naslov		Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma
Tip		članek
Vol. in št.		Letnik 33, št. 3
Leto izdaje		2016
Obseg		str. 357-368
ISSN		0741-238X - Advances in therapy
Jezik		eng
Abstrakt		Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
Proste vsebinske oznake		rak glave in vratu adenoidni cistični karcinom žleze slinavke limfne metastaze head and neck cancer adenoid cystic carcinoma lymphatic metastasis salivary glands