Avtor/Urednik		Rades, Dirk; Conde-Moreno, Antonio J.; Cacicedo, Jon; Šegedin, Barbara; Veninga, Theo; Schild, Steven E.
Naslov		Metastatic spinal cord compression
Tip		članek
Vol. in št.		Letnik 35, št. 11
Leto izdaje		2015
Obseg		str. 6189-6192
ISSN		0250-7005 - Anticancer research
Jezik		eng
Abstrakt		Metastatic spinal cord compression (MSCC) is an oncological emergency. Many elderly patients cannot tolerate intensive treatment and need individual approaches accounting for a patient's remaining lifetime. The goal of the present study was to develop a survival score for elderly prostate cancer patients with MSCC. PATIENTS AND METHODS: Nine characteristics were analyzed in 243 patients: age, performance status, interval from prostate cancer diagnosis until MSCC, affected vertebrae, ambulatory status, further bone lesions, visceral metastases, time developing motor deficits, fractionation schedule. RESULTS: Pre-radiotherapy ambulatory status (p<0.001), visceral metastases (p<0.001) and time developing motor deficits (p<0.001) were significant for survival on Cox regression analysis and included in the survival score. Four groups were defined: 9-12, 13-16, 17-19 and 21-23 points. Six-month survival rates were 7%, 28%, 71% and 95%, respectively (p<0.001). CONCLUSION: The present study identified four groups with different survival probabilities that require treatment strategies with different priorities ranging from symptom control to prolongation of life.
Proste vsebinske oznake		rak prostate iradiacija starejši bolniki radioterapija preživetje celokupno preživetje prostate cancer elderly patients radiotherapy overall survival irradiation