Avtor/Urednik		Ihan, A; Križman, I; Ferlan-Marolt, V; Tepež, B; Gubina, M
Naslov		HLA-DR expression on CD8 lymphocytes from gastric mucosa in urease-positive and urease-negative gastritis
Tip		članek
Vir		FEMS Immunol Med Microbiol
Vol. in št.		Letnik 10, št. 3-4
Leto izdaje		1995
Obseg		str. 295-9
Jezik		eng
Abstrakt		We isolated lymphocytes from chronically inflamed gastric mucosa. We analysed the expression of IL-2 receptors (CD25), transferin receptors (CD71) and HLA-DR molecules on T lymphocytes by flow cytometric analysis in 16 patients with urease-positive and in 7 patients with urease-negative chronic gastritis. In G0, G1 and G2 histological type (Sydney classification) of gastritis the number of lymphocytes obtained from the gastric mucosa biopsies was too low for the flow cytometric analysis. However, in G3 histological type of chronic gastritis we obtained enough cells for the flow cytometric analysis in 75 percent. We demonstrated a significant increase in HLA-DR expression on CD8 cells from patients with urease-positive gastritis compared to urease-negative gastritis. We also observed a statistically non-significant increase in HLA-DR expression on CD3 cells, and in CD71 expression on both CD3 and CD8 cells in urease-positive gastritis. However, no difference in CD25 expression was found between the two types of gastritis.
Deskriptorji		CD8-POSITIVE T-LYMPHOCYTES GASTRITIS HLA-DR ANTIGENS UREASE ANTIGENS, CD3 CHRONIC DISEASE FLOW CYTOMETRY GASTRIC MUCOSA HELICOBACTER PYLORI HELICOBACTER INFECTIONS LYMPHOCYTE COUNT RECEPTORS, INTERLEUKIN-2 RECEPTORS, TRANSFERRIN