Avtor/Urednik | Seidl, Daniel; Janssen, Stefan; Strojan, Primož; Bajrovic, Amira; Schild, Steven E.; Rades, Dirk | |
Naslov | Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer | |
Tip | članek | |
Vol. in št. | Letnik 36, št. 5 | |
Leto izdaje | 2016 | |
Obseg | str. 2523-2526 | |
ISSN | 0250-7005 - Anticancer research | |
Jezik | eng | |
Abstrakt | To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m(2) of cisplatin weekly, three courses of cisplatin 100 mg/m(2), two courses of cisplatin 5x20 mg/m(2) or two courses of cisplatin 5%20 mg/m(2)plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. RESULTS: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS %80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m(2) or 5%20 mg/m(2) (p<0.001) were predictors of improved OS. CONCLUSION: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted. | |
Proste vsebinske oznake | rak glave in vratu radioterapija ploščatocelični rak preživetje head and neck cancer radiotherapy squamous cell carcinoma overall survival |