Avtor/Urednik		Jurič, Damijana Mojca; Kržan, Mojca; Lipnik-Štangelj, Metoda
Naslov		Histamine and astrocyte function
Tip		članek
Vol. in št.		, št. Vol. 111
Leto izdaje		2016
Obseg		str. 774-783
ISSN		1043-6618 - Pharmacological research : the official journal of the Italian Pharmacological Society
Jezik		eng
Abstrakt		Astrocytes support the brain through numerous functional interactions in health and disease. The recent advances in our knowledge of astrocyte involvement in various neurological disorders raised up several questions about their role and functioning in the central nervous system. From the evidence discussed in this review, we show that histamine importantly influences the main astrocytic activities such as ion homeostasis, energy metabolism, neurotransmitter clearance, neurotrophic activity and immune response. These processes are mediated through at least three histamine receptor subtypes, H1, H2 and H3, expressed on the astrocyte surface. Thus, we recognize histamine as an important player in the modulation of astrocytic functions that deserves further considerations in exploring involvement of astrocytes in neurological disorders.
Proste vsebinske oznake		histamine histamine receptors astrocyte function