Avtor/Urednik		Petrič, Rok; Gazić, Barbara; Goričar, Katja; Dolžan, Vita; Dzodić, Radan; Bešić, Nikola
Naslov		Expression of miRNA and occurrence of distant metastases in patients with Hürthle cell carcinoma
Tip		članek
Leto izdaje		2016
ISSN		1687-8337 - International journal of endocrinology
Jezik		eng
Abstrakt		Hürthle cell thyroid carcinoma (HCTC) is a rare type of thyroid carcinoma. In the present study, we investigated whether the expression of miRNAs of interest is associated with the occurrence of metastases in patients with HCTC. Materials and Methods. In 39 patients with HCTC (22 with nonmetastatic and 17 with regional or distant metastatic disease), the expression levels of six miRNAs (miR-138, miR-183, miR-221, miR-222, miR-768-3p, and miR-885-5p) and U6 snRNA as endogenous control were determined in FFPE samples of primary tumor and normal thyroid tissue using TaqMan miRNA assays. Results. In patients with HCTC, miR-138 and miR-768-3p were downregulated in tumor samples compared to normal tissue ( and , resp.). These two miRNAs were also significantly downregulated in tumor samples of patients with metastatic disease ( and , resp.) but not in patients with nonmetastatic disease ( and , resp.). In patients with nonmetastatic disease, miR-221 and miR-885-5p were slightly, albeit significantly, upregulated in tumorous compared to normal tissue ( and , resp.). Conclusion. Expression of miRNA (miR-183, miR-221, and miR-885-5p) in tumor tissue is associated with the occurrence of distant metastases in patients with HCTC.
Proste vsebinske oznake		Hürthlejev rak rak ščitnice Hürthlejev celični karcinom metastaze Hürthle cell carcinoma thyroid carcinoma metastases HCTC