Avtor/Urednik		Lenarčič, B; Krašovec, M; Ritonja, A; Olafsson, I; Turk, V
Naslov		Inactivation of human cystatin C and kininogen by human cathepsin D
Tip		članek
Vir		FEBS Lett
Vol. in št.		Letnik 280, št. 2
Leto izdaje		1991
Obseg		str. 211-5
Jezik		eng
Abstrakt		A papain inhibitor of 22 kDa was isolated from human placenta and shown to be identical to residues Cys246-Leu373 of the third domain of human kininogen. This kininogen domain and recombinant human cystatin C were inactivated by peptide bond cleavages at hydrophobic amino acid residues due to the action of cathepsin D. These results further support the proposed role of cathepsin D in the regulation of cysteine proteinase activity.
Deskriptorji		CATHEPSIN D CYSTATINS KININOGENS AMINO ACID SEQUENCE CHROMATOGRAPHY, HIGH PRESSURE LIQUID CYSTEINE PROTEINASES ENZYME ACTIVATION KININOGENS MOLECULAR SEQUENCE DATA PLACENTA PROTEIN DENATURATION RECOMBINANT PROTEINS