Avtor/Urednik     Kobal, Jan; Cankar, Ksenija; Pretnar-Oblak, Janja; Zaletel, Marjan; Kobal, Lucijan; Teran, Nataša; Melik, Živa
Naslov     Functional impairment of precerebral arteries in Huntington disease
Tip     članek
Vol. in št.     Letnik 372, št. 1
Leto izdaje     2017
Obseg     str. 363-368
ISSN     0022-510X - Journal of the neurological sciences
Jezik     eng
Abstrakt     BACKGROUND: Cardiovascular pathology of Huntington disease (HD) appears to be complex; while microvascular dysfunction seems to appear early, deaths from cardiomyopathy and stroke might occur in the late phase of HD. METHODS: Our study evaluated global risk factors for coronary heart disease (CHD), structure and function of precerebral arteries in 41 HD subjects and 41 matched controls. HD subjects were divided into groups by the United Huntington disease rating scale (presymptomatic-PHD, early-EHD, midstage-MHD and late-LHD). CHD risk factors assessment and Doppler examination of precerebral arteries were performed, including measurements of the carotid artery intima-media thickness (IMT), and parameters indicating local carotid artery distensibility (stiffness index %, pulse wave velocity, pressure strain elasticity module and carotid artery compliance). RESULTS: In the HD and controls we identified a comparable number of non-obstructive plaques (<50% lumen narrowing). No obstructive plaques (>50% lumen narrowing) were found. There was significantly increased IMT in MHD. In PHD and EHD the parameters of arterial stiffness were significantly higher and the carotid artery compliance was significantly lower. CONCLUSIONS: Our results reveal functional vascular pathology in PHD, EHD, and MHD. Precerebral arteries dysfunction in HD therefore appears to be mostly functional and in agreement with recently described autonomic nervous system changes in HD.
Proste vsebinske oznake     arterije
delovanje avtonomnega živčnega sistema
Huntingtonova bolezen
ultrasonografija
arterial stiffness parameters
autonomic nervous system activity
Huntington disease
ultrasonography