Avtor/Urednik		Cary, Daniele C.; Peterlin, Matija Boris
Naslov		Targeting the latent reservoir to achieve functional HIV cure
Tip		članek
Vol. in št.		, št. Vol. 5
Leto izdaje		2016
Obseg		str. 1-8
Jezik		eng
Abstrakt		While highly active anti-retroviral therapy has greatly improved the lives of HIV-infected individuals, current treatments are unable to completely eradicate the virus. This is due to the presence of HIV latently infected cells which harbor transcriptionally silent HIV. Latent HIV does not replicate or produce viral proteins, thereby preventing efficient targeting by anti-retroviral drugs. Strategies to target the HIV latent reservoir include viral reactivation, enhancing host defense mechanisms, keeping latent HIV silent, and using gene therapy techniques to knock out or reactivate latent HIV. While research into each of these areas has yielded promising results, currently no one mechanism eradicates latent HIV. Instead, combinations of these approaches should be considered for a potential HIV functional cure.
Proste vsebinske oznake		virus HIV anti-retroviral therapy functional cure virus HIV protivirusno zdravljenje funkcionalno zdravljenje