Avtor/Urednik		Gregorc, K; Kristl, J; Gabrijelčič, V; Šentjurc, M; Šmid-Korbar, J
Naslov		Physical stability of liposomes studied by EPR method
Prevedeni naslov		Proučevanje fizikalne stabilnosti liposomov z EPR metodo
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 46, št. 2
Leto izdaje		1995
Obseg		str. 119-26
Jezik		eng
Abstrakt		Multilamellar and small unilamellar vesicles (MLV, SUV) with entrapped hydrophilic paramagnetic probe N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-N,N-dimethyl-N-hydroxyethylammoniumdiodide (ASL) were prepared in water and dispersed in hydrogels of different hydrophilic polymers (xanthan gum, carboxymethylcellulose sodium). The physical stability of liposomes has been investigated by electron paramagnetic resonance (EPR) method measuring the amount of ASL released after its encapsulation into liposomes. On-going stability study shows that egg yolk lecithin and alpha-tocopherol acetate liposomes are more stable than soya lecithin liposomes, regardless of the dispersion medium composition. The results also show that some hydrophilic polymers and preservatives present in dispersion medium, influence the physical stability of liposomes.
Deskriptorji		LIPOSOMES DRUG STABILITY ELECTRON SPIN RESONANCE SPECTROSCOPY PHOSPHATIDYLCHOLINES VITAMIN E